| 6-27 | PJ Franks | Nottinghamshire v Durham | 2000 | a12747 |
| 6-30 | SJE Brown | Durham v Northamptonshire | 1997 | a10456 |
| 6-51 | AW Laraman | Middlesex v Durham | 2000 | a12804 |
| 5-9 | DA Leatherdale | Worcestershire v Durham | 2002 | a14345 |
| 5-28 | GP Swann | England v Australia | 2009 | a19987 |
| 5-29 | AJ Hollioake | Surrey v Durham | 2000 | a12708 |
| 5-31 | VC Drakes | Nottinghamshire v Durham | 1999 | a12075 |
| 5-31 | C Rushworth | Durham v Nottinghamshire | 2012 | a21995 |
| 5-33 | PLS Gamage | Sri Lanka A v Durham | 2014 | a23408 |
| 5-33 | UT Yadav | Middlesex v Durham | 2022 | a29336 |
| 5-35 | GP Swann | Northamptonshire v Durham | 1999 | a11987 |
| 5-35 | Shoaib Akhtar | Durham v Somerset | 2003 | a15229 |
| 5-41 | GR Breese | Durham v Derbyshire | 2008 | a19008 |
| 5-42 | JEC Franklin | New Zealand v England | 2004 | a15960 |
| 5-42 | C Rushworth | Durham v Hampshire | 2013 | a22702 |
| 5-45 | RJ Bailey | Derbyshire v Durham | 2000 | a12675 |
| 5-46 | Z de Bruyn | Surrey v Durham | 2012 | a22082 |
| 5-48 | ML Lewis | Durham v Sussex | 2005 | a16594 |
| 5-48 | N Killeen | Durham v Gloucestershire | 2009 | a19821 |
| 5-49 | GR Breese | Durham v Worcestershire | 2007 | a18247 |
| 5-51 | HF Gurney | Nottinghamshire v Durham | 2016 | a24788 |