| 184 | JG Langridge | Sussex v Derbyshire | 1950 | f18839 |
| 151 | PB Wight | Somerset v Derbyshire | 1963 | f24721 |
| 143 | GO Dawkes | Derbyshire v Hampshire | 1954 | f20548 |
| 143 | PH Parfitt | Middlesex v Derbyshire | 1964 | f25291 |
| 142 | MJK Smith | Warwickshire v Derbyshire | 1959 | f22838 |
| 140* | AJ Lamb | Northamptonshire v Derbyshire | 1979 | f32682 |
| 131 | JG Wright | Derbyshire v Northamptonshire | 1979 | f32682 |
| 123 | WR Hammond | Gloucestershire v Derbyshire | 1938 | f16174 |
| 120 | BR Knight | Essex v Derbyshire | 1961 | f23774 |
| 117 | GA Edrich | Lancashire v Derbyshire | 1952 | f19660 |
| 116 | JM Kelly | Derbyshire v Hampshire | 1954 | f20548 |
| 116 | C Lee | Derbyshire v Leicestershire | 1956 | f21381 |
| 114 | L Harrison | Hampshire v Derbyshire | 1954 | f20548 |
| 113 | D Smith | Derbyshire v Gloucestershire | 1938 | f16174 |
| 110 | WR Hammond | Gloucestershire v Derbyshire | 1938 | f16174 |
| 110* | AJ Harvey-Walker | Derbyshire v Oxford University | 1971 | f28745 |
| 108 | CC Inman | Leicestershire v Derbyshire | 1968 | f27395 |
| 107* | J Langridge | Sussex v Derbyshire | 1948 | f18030 |
| 100 | DI Gower | Leicestershire v Derbyshire | 1980 | f33124 |