| 7-15 | GD McGrath | Australia v Namibia | 2002/03 | o1970 |
| 5-44 | J Theron | South Africa v Zimbabwe | 2010/11 | o3059 |
| 4-16 | L Klusener | South Africa v Kenya | 2002/03 | o1948 |
| 4-16 | DW Steyn | South Africa v Bangladesh | 2008/09 | o2771 |
| 4-23 | E Schiferli | Netherlands v Kenya | 2008/09 | o2844 |
| 4-33 | M Ntini | South Africa v Australia | 2001/02 | o1821 |
| 4-33 | JH Kallis | South Africa v Bangladesh | 2002/03 | o1890 |
| 4-45 | B Lee | Australia v South Africa | 2001/02 | o1821 |
| 4-45 | LL Tsotsobe | South Africa v New Zealand | 2012/13 | o3328 |
| 4-49 | E Schiferli | Netherlands v Kenya | 2008/09 | o2831 |
| 4-50 | GW Coetzee | South Africa v Australia | 2023/24 | o4642 |
| 4-52 | R McLaren | South Africa v New Zealand | 2012/13 | o3328 |
| 4-65 | Talha Jubair | Bangladesh v South Africa | 2002/03 | o1890 |