| 5 | JH Kallis | Australia v South Africa | 2008/09 | t1910 |
| 4 | DJ Insole | South Africa v England | 1956/57 | t434 |
| 4 | TL Goddard | England v South Africa | 1956/57 | t434 |
| 4 | WR Endean | England v South Africa | 1956/57 | t437 |
| 4 | MJK Smith | South Africa v England | 1964/65 | t572 |
| 4 | EJ Barlow | England v South Africa | 1964/65 | t575 |
| 4 | MD Crowe | South Africa v New Zealand | 1994/95 | t1276 |
| 4 | GC Smith | Sri Lanka v South Africa | 2002/03 | t1624 |
| 4 | AB de Villiers | New Zealand v South Africa | 2005/06 | t1801 |
| 4 | V Sehwag | South Africa v India | 2006/07 | t1823 |