| 5 | ATW Grout | South Africa v Australia | 1957/58 | t447 |
| 5 | NR Mongia | South Africa v India | 1996/97 | t1347 |
| 5 | BJ Haddin | South Africa v Australia | 2008/09 | t1913 |
| 5 | MV Boucher | India v South Africa | 2010/11 | t1987 |
| 5 | AB de Villiers | India v South Africa | 2013/14 | t2111 |
| 4 | G Duckworth | South Africa v England | 1930/31 | t204 |
| 4 | AE Dick | South Africa v New Zealand | 1961/62 | t515 |
| 4 | JHB Waite | New Zealand v South Africa | 1961/62 | t515 |
| 4 | DJ Richardson | New Zealand v South Africa | 1994/95 | t1280 |
| 4 | AJ Stewart | South Africa v England | 1999/00 | t1480 |
| 4 | AJ Stewart | South Africa v England | 1999/00 | t1480 |
| 4 | MV Boucher | Sri Lanka v South Africa | 2000/01 | t1526 |
| 4 | AC Gilchrist | South Africa v Australia | 2001/02 | t1595 |
| 4 | MV Boucher | Pakistan v South Africa | 2002/03 | t1635 |
| 4 | AB de Villiers | England v South Africa | 2004/05 | t1730 |
| 4 | MV Boucher | India v South Africa | 2006/07 | t1825 |
| 4 | MV Boucher | India v South Africa | 2010/11 | t1987 |
| 4 | MV Boucher | Sri Lanka v South Africa | 2011/12 | t2026 |
| 4 | LD Chandimal | South Africa v Sri Lanka | 2011/12 | t2026 |
| 4 | AB de Villiers | England v South Africa | 2015/16 | t2196 |
| 4 | TD Paine | South Africa v Australia | 2017/18 | t2297 |