| 4 | GC Smith | Zimbabwe v South Africa | 2004/05 | t1740 |
| 4 | HH Gibbs | Pakistan v South Africa | 2006/07 | t1828 |
| 4 | Younis Khan | South Africa v Pakistan | 2006/07 | t1828 |
| 4 | PD Collingwood | South Africa v England | 2009/10 | t1942 |
| 4 | JH Kallis | Sri Lanka v South Africa | 2011/12 | t2023 |
| 4 | M Vijay | South Africa v India | 2017/18 | t2293 |
| 3 | JH Kallis | West Indies v South Africa | 1998/99 | t1441 |
| 3 | D Ganga | South Africa v West Indies | 1998/99 | t1441 |
| 3 | ME Trescothick | South Africa v England | 2004/05 | t1736 |
| 3 | SB Styris | South Africa v New Zealand | 2005/06 | t1798 |
| 3 | AB de Villiers | New Zealand v South Africa | 2007/08 | t1848 |
| 3 | GC Smith | Bangladesh v South Africa | 2008/09 | t1895 |
| 3 | AN Cook | South Africa v England | 2009/10 | t1942 |
| 3 | GC Smith | Pakistan v South Africa | 2012/13 | t2075 |
| 3 | D Elgar | Pakistan v South Africa | 2012/13 | t2075 |
| 3 | MJ Clarke | South Africa v Australia | 2013/14 | t2119 |
| 3 | AN Petersen | West Indies v South Africa | 2014/15 | t2150 |
| 3 | M Morkel | India v South Africa | 2017/18 | t2293 |
| 3 | JE Root | South Africa v England | 2019/20 | t2377 |