| 167 runs | Middlesex v Lancashire | Lord's Cricket Ground, St John's Wood | a22011 |
| 164 runs | Gloucestershire v Leicestershire | County Ground, Bristol | a21973 |
| 144 runs | Sussex v Unicorns | The PROBIZ County Ground, Hove | a21975 |
| 142 runs | Durham v Surrey | Emirates Durham International Cricket Ground, Chester-le-Street | a22083 |
| 129 runs | Derbyshire v Unicorns | Sir Paul Getty's Ground, Wormsley | a21963 |
| 117 runs | Essex v Netherlands | Castle Park Cricket Ground, Colchester | a22092 |
| 111 runs | Kent v Derbyshire | St Lawrence Ground, Canterbury | a22085 |
| 109 runs | Gloucestershire v Worcestershire | County Ground, New Road, Worcester | a22013 |
| 107 runs | Hampshire v Glamorgan | The SWALEC Stadium, Cardiff | a22082 |
| 105 runs | Surrey v Somerset | The Kia Oval, Kennington | a21959 |
| 105 runs | Warwickshire v Derbyshire | County Ground, Derby | a21998 |